Keratopigmentation is an advanced ophthalmic technique designed to introduce biocompatible pigments in order to correct corneal abnormalities or achieve a change in eye color. This procedure provides long-lasting results while preserving the integrity of the eye.
BIOCHROMAEYES® and BIOCHROMAEYES® Aesthetic stand out through their high-precision pigments, specifically developed to ensure safety, stability, and a natural-looking result, positioning the company as a leader in this field at the crossroads of medical reconstruction and aesthetics.
Discover the major milestones in the development of keratopigmentation by BIOTIC Phocea Labora
1999 — First sterile pigment
First sterile single-use pigment approved as a Class IIb CE medical device.
2011 — Creation of the BIOCHROMAEYES® pigment
Development of a fully biocompatible pigment for therapeutic corneal applications.
2015 — Aesthetic ophthalmic pigment
Launch of the first aesthetic ophthalmic pigment designed for eye color change.
2022 — REACH Compliance
First manufacturer to offer tattoo pigments compliant with REACH regulations.
2025 — Patented BIOCHROMAEYES® Aesthetic Technology
New generation of patented pigments for aesthetic keratopigmentation of the eyes.
BIOCHROMAEYES® pigments, specifically designed for keratopigmentation, are the only ones to have obtained CE Class IIb medical certification for therapeutic use, guaranteeing compliance with the highest standards of safety and efficacy.
Developed after several years of research and collaboration with internationally renowned scientists and ophthalmic surgeons, BIOCHROMAEYES® pigments benefit from safety supported by numerous scientific publications.
Among these, a study conducted by Professor Alió in 2024 mentioned an isolated case of MRI-related reaction, without questioning the overall safety of the product, which continues to be supported by extensive positive clinical experience.
Many ophthalmologists and keratopigmentation experts continue to emphasize the reliability and biocompatibility of our pigments, which are regularly cited in scientific literature. No major adverse effects have been observed under normal conditions of use, with the rare reported incidents most often linked to individual factors.
In the medical field, validation through clinical experience and feedback from healthcare professionals remains essential. Thanks to their CE Class IIb certification and extensive clinical track record, BIOCHROMAEYES® pigments are now recognized worldwide as a safe and proven reference.
While new product ranges continue to appear on the market, few offer an equivalent level of scientific validation and medical certification. In the absence of long-term biocompatibility evidence, caution remains essential: demand verified clinical data.
Remaining true to our commitment, BIOTIC Phocea Laboratories continue their mission: to provide certified, validated, and scientifically recognized solutions dedicated to patient safety and medical excellence.